Epilepsy Research

The Latest in Epilepsy Research

The Epilepsy Foundation of Connecticut supports the work of the Epilepsy Therapy Project to promoted the discovery of new treatments for epilepsy and bring those treatments to you faster. One of the fundamental building blocks to achieve this is clinical research.

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Ongoing Clinical Trials

  • Providence VA Medical Center: Neuroimaging Biomarker for Seizures

    Brief Summary:

    This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.

    Inclusion Criteria:

    Inclusion criteria for PNES, ES and TBI (w/o PNES or ES) participants
    - Individuals with history of documented TBI (any severity).
    - Males and Females ages 18-60 years.
    - Women of child bearing potential, if currently using appropriate contraception.

    Inclusion criteria of PNES and ES participants.
    - Diagnosed by video/EEG with lone PNES or by EEG with lone ES.
    - Patients must have at least 1 PNES or 1 ES during the year prior to enrollment.

    Sponsor:

    Providence VA Medical Center

    Contacts:

    W. Curt LaFrance, Jr., MD, MPH 401-273-7100 ext 2441 william_lafrance_jr@brown.edu
    Krista Tocco, BA 401-273-7100 ext 6229 Krista.Tocco@va.gov

  • Yale: New Onset Refractory Status Epilepticus (NORSE)

    INCLUSION CRITERIA
    At least 6 years old SE refractory to first- and second-line therapy No etiology found in the first 24 hours

    EXCLUSION CRITERIA
    Major ongoing acute or subacute medical issues

    PATIENT COMMITMENT AND SUPPORT
    2 years total enrollment Follow-up at 3-6, 12, 24 months postdischarge Bio-specimen collection No direct benefit to patient

  • Yale: Patient-Detectable Responsive Neurostimulation System (RNS)

    INCLUSION CRITERIA
    Age ≥18 yrs Surgical work-up localized no more than 2 epileptogenic foci

    EXCLUSION CRITERIA
    Primary generalized seizures

    PATIENT COMMITMENT AND SUPPORT
    Regular care visits Mood questionnaire Maintain seizure diary $50 per study visit.

    For further information, contact the study coordinator(s) Paulina Henriquez| paulina.henriquezrojas@yale.edu | 312-856-2356

  • Yale: Human Epilepsy Project 2 (HEP)

    INCLUSION CRITERIA
    Between 16 and 65 years old at time of enrollment History of focal epilepsy Failure of adequate trials of 4 AEDs, with at least 2 due to failure of sz control, including current AEDs >≥4 seizures per month, including auras, ≥2 or more observable seizures observable for 3 months prior to enrollment

    EXCLUSION CRITERIA
    Idiopathic generalized epilepsy Progressive medical or neuro condition Planned epilepsy surgery Previous epilepsy surgery in last 12 months Severe development or cognitive delay Proven autoimmune etiology Hx of chronic drug or alcohol abuse

    For further information, contact the study coordinator(s) Abiha Jafri | abiha.jafri@yale.edu | 203-785-5585

Epilepsy Treatment & Research Links

CDC - Centers for Disease control & prevention
CDC conducts or supports research to strengthen the public health science base and to guide public health practice.

Clinical Trials.gov
ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world.

CURE (Citizens united for Research in Epilepsy)
Citizens United for Research in Epilepsy is a nonprofit organization dedicated to finding a hublot replica cure for epilepsy by raising funds for research and by increasing awareness of the prevalence and devastation of this disease.

FACES - Finding A Cure For Epilepsy & Seizures
Website for Finding A Cure for Epilepsy and Seizures (faces). Faces supports epilepsy research, education and awareness, and community building events for all people with epilepsy.

National Institute of Neurological Disorders & Stroke
Website about ongoing research that is focused on developing new model systems that can be used to more quickly screen potential new treatments for the epilepsies.

Epilepsy Research


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