This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.
Inclusion criteria for PNES, ES and TBI (w/o PNES or ES) participants
Individuals with history of documented TBI (any severity).
Males and Females ages 18-60 years.
Women of child bearing potential, if currently using appropriate contraception.
Inclusion criteria of PNES and ES participants.
Diagnosed by video/EEG with lone PNES or by EEG with lone ES.
Patients must have at least 1 PNES or 1 ES during the year prior to enrollment.
INCLUSION CRITERIA At least 6 years old SE refractory to first- and second-line therapy No etiology found in the first 24 hours
Major ongoing acute or subacute medical issues
PATIENT COMMITMENT AND SUPPORT
2 years total enrollment Follow-up at 3-6, 12, 24 months postdischarge Bio-specimen collection No direct benefit to patient
Patient-Detectable Responsive Neurostimulation System
INCLUSION CRITERIA Age ≥18 yrs Surgical work-up localized no more than 2 epileptogenic foci
Primary generalized seizures
For further information, contact the study coordinator(s) Paulina Henriquez| email@example.com | 312-856-2356
PATIENT COMMITMENT AND SUPPORT Regular care visits Mood questionnaire Maintain seizure diary $50 per study visit
Human Epilepsy Project 2
INCLUSION CRITERIA Between 16 and 65 years old at time of enrollment History of focal epilepsy Failure of adequate trials of 4 AEDs, with at least 2 due to failure of sz control, including current AEDs >≥4 seizures per month, including auras, ≥2 or more observable seizures observable for 3 months prior to enrollment
Idiopathic generalized epilepsy Progressive medical or neuro condition Planned epilepsy surgery Previous epilepsy surgery in last 12 months Severe development or cognitive delay Proven autoimmune etiology Hx of chronic drug or alcohol abuse
For further information, contact the study coordinator(s) Abiha Jafri | firstname.lastname@example.org | 203-785-5585