Providence VA Medical Center

Neuroimaging Biomarker for Seizures

Brief Summary:

This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.

Inclusion Criteria:

Inclusion criteria for PNES, ES and TBI (w/o PNES or ES) participants
  • Individuals with history of documented TBI (any severity).
  • Males and Females ages 18-60 years.
  • Women of child bearing potential, if currently using appropriate contraception.


Inclusion criteria of PNES and ES participants.
  • Diagnosed by video/EEG with lone PNES or by EEG with lone ES.
  • Patients must have at least 1 PNES or 1 ES during the year prior to enrollment.

Sponsor:

Providence VA Medical Center

Contacts:

W. Curt LaFrance, Jr., MD, MPH 401-273-7100 ext 2441 william_lafrance_jr@brown.edu
Krista Tocco, BA 401-273-7100 ext 6229 Krista.Tocco@va.gov


Yale

NORSE
New Onset Refractory Status Epilepticus

INCLUSION CRITERIA At least 6 years old SE refractory to first- and second-line therapy No etiology found in the first 24 hours

EXCLUSION CRITERIA
Major ongoing acute or subacute medical issues

PATIENT COMMITMENT AND SUPPORT
2 years total enrollment Follow-up at 3-6, 12, 24 months postdischarge Bio-specimen collection No direct benefit to patient

RNS
Patient-Detectable Responsive Neurostimulation System

INCLUSION CRITERIA Age ≥18 yrs Surgical work-up localized no more than 2 epileptogenic foci

EXCLUSION CRITERIA
Primary generalized seizures

For further information, contact the study coordinator(s) Paulina Henriquez| paulina.henriquezrojas@yale.edu | 312-856-2356 PATIENT COMMITMENT AND SUPPORT Regular care visits Mood questionnaire Maintain seizure diary $50 per study visit

HEP2
Human Epilepsy Project 2

INCLUSION CRITERIA Between 16 and 65 years old at time of enrollment History of focal epilepsy Failure of adequate trials of 4 AEDs, with at least 2 due to failure of sz control, including current AEDs >≥4 seizures per month, including auras, ≥2 or more observable seizures observable for 3 months prior to enrollment

EXCLUSION CRITERIA
Idiopathic generalized epilepsy Progressive medical or neuro condition Planned epilepsy surgery Previous epilepsy surgery in last 12 months Severe development or cognitive delay Proven autoimmune etiology Hx of chronic drug or alcohol abuse

For further information, contact the study coordinator(s) Abiha Jafri | abiha.jafri@yale.edu | 203-785-5585

© 2021 Epilepsy Foundation Connecticut